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[16:49:59] Invitado[CentroBiotecnologia] :

Hi Dra. nice presentation, my question is about the role of TETs proteins, they inhibit metilation of regions of genes that codifies proteíns that supresses tumoral cells or what kind of participation?

[16:52:52] Invitado[Plicona] :

I have a question regarding the chronic exposure of antigen in the tumor model to promote exhaustion. Vgr if you make the tumor to express the P14 antigen in enough to make those TILs exhausted and can you make them exhausted only with the activation of the NFAT pathway exvivo P14 isolated from the B16OVA plus iono)

[16:55:40] Invitado[Plicona] :

kind of

[16:56:22] Invitado[Plicona] :

I wannted to know if the exvivo stimulation of P14 TIL with iono is enough to make them exhausted

[16:57:03] Invitado[Plicona] :

thanks

[16:57:32] Invitado[liconaslab] :

Can you prevent CD8 exhaustion by preactivating T cells in vitro? And then trasnfering to the mice